Skip to text Skip to main menu

CELLPURICS

CRO SERVICE

In Vivo Drug Efficacy Evaluation Service

We provide in vivo drug efficacy evaluation services for our customers to help them obtain
reliable and accurate results using various biological models for their R&D of new drugs.

Evaluation of Cancer Immunotherapy Efficacy Using Humanized Mice

Biocytogen PBMC/CD34+HSC humanized mouse anti-cancer
efficacy test platform Introduced to Korea

We provide in vivo drug efficacy evaluation services for our customers to help them obtain reliable and
accurate results using various biological models for their R&D of new drugs.

  • 01
    Developed by Biocytogen, the B-NDG mouse models are deficient in T-cells, B-cells, and functional NK-cells and highly suitable for anti-cancer efficacy testing after the creation of humanized mice.
  • 02
    Biocytogen has various types of B-NDG models and provides a platform for various in vivo efficacy evaluations according to the target of new anticancer drugs by humanizing mice transplantation of human immune cells (PBMC/CD34+).
  • 03
    We provide a commissioned efficacy evaluation using all of Biocytogen's mouse models.

Biocytogen's PBMC or
CD34+HSC Humanized Mouse Platform for Anti-Cancer Tests

Reconstitution type Product name Product ID Features and application
No need
to reconstitute		 B-NDG mice 110586

No mature T or B cells, no NK cells
B-NDG hairless mice 110598

Hairless, easy to measure tumor
B-NDG nude mice 110587

Hairless, easy to measure tumor
B-NDG hFcRn mice 111922

PK (NDG background can reduce ADA)
PBMC B-NDG B2m KO mice plus 110601

No MHC class I molecule expression

Reduce GvHD and prolong the experimental window period

Improve the accuracy of efficacy verification
B-NDG MHC I/II DKO mice plus 111895

No MHC class I/II molecule expression

Reduce GvHD and prolong the experimental window period

Improve the accuracy of efficacy verification
NK
HSC		 B-NDG hIL15 mice 110600

Promote differentiation of human NK cells
B-NDG hIL7/hIL15 mice 120612

Promote differentiation of human T cells and NK cells
B-NDG hIL15, FcγR KO mice 112653

Promote differentiation of human NK cells

No mouse Fc receptor function
HSC B-NDG hCSF1/hTHPO mice 120609

Irradiation not required

Promote human myeloid cell development,
especially monocyte-macrophage differentiation
B-NDG hIL6 mice 110596

Promote differentiation of human monocyte-macrophage
B-NDG hTHPO mice 110590

Irradiation is not required to avoid damage to mice caused by irradiation
B-NDG MGMT3 mice 111882

Promote differentiation of human myeloid cells

Irradiation is not required to avoid damage to mice caused by irradiation
B-NDG HLA-A2.1 mice 110599

To verify the efficacy of HLA-A2.1 restricted vaccines

Promote the development of human CD8+ T cells
B-NDG HLA-A2.1 mice plus 112449

vaccines and antibody-based therapiesvaccinesand
antibody-based therapies

Promote the development of human CD8+ T cells
B-NDG Hc mice 110605

Verify drug efficacy for CDC